Monday, 01 April 2019

8.30 Registration
9.00 Welcome and Introduction
General Introduction: Gerhard Winter - Ludwig-Maximilians-Universität München
PIPPI Introduction: Pernille Harris - Technical University of Denmark
9.30

Session 1: Protein formulation
Invited Speaker: John Carpenter – University of Colorado

Interactions of stabilizing excipients with proteins in aqueous solution, during freezing and during dehydration - If you don't know about the Timasheff mechanism, you don't know anything of importance for protein formulation

Short Lectures:

Maria-Laura Greco / Shahid Uddin & Chris van de Walle – Astra Zeneca
A formulation study of Antibody drug conjugates

Inas El Bialy / Wolfgang Friess - Ludwig-Maximilians-Universität München
Interfacial Activity of Monoclonal Antibodies and its Impact on Formulation Stability

Anja Thalhammer – University of Potsdam
Rapid-acting and human insulins: Hexamer dissociation kinetics upon dilution of the pharmaceutical formulation

11.00 Coffee Break, posters will be mounted
11.30

Session 2: Structural Biology
Invited Speaker: Tom Laue – University of New Hampshire

Interactions in high concentration, complex solutions

Short Lectures:

Matja Zalar / Alexander Golovanov – University of Manchester
Characterisation of protein excipient interactions and their effect on protein aggregation

Alina Kulakova / Pernille Harris - Technical University of Denmark
Stability studies on HSA-NEP conjugate

Max Uttinger – Friedrich-Alexander-Universität Erlangen-Nürnberg
Investigation of hydrodynamic and thermodynamic non-ideality parameters by analytical ultracentrifugation

13.00

Lunch Break, Poster Session
Exhibitors lunch talks

14.20-14.30 Beckman Coulter

14.30-14.40 Waters

14.40-14.50 Wyatt Technology

15.00

Session 3: Protein Stability
Invited Speaker: Ulla Elofsson – RISE Research Institutes of Sweden

Novel Approaches for Mechanistic Understanding of Protein stability

Short Lectures:

Hristo Svilenov / Gerhard Winter – Ludwig-Maximilians-Universität München
Formulation of therapeutic proteins - Connecting protein unfolding, refolding, aggregation and long-term storage stability

Sujata Mahapatra / Werner Streicher – Novozymes
Interaction studies of monoclonal antibodies at highly concentrated solutions

16.10 Coffee Break, Posters Are Up
16.30

Session 4: Protein Data Analytics
Invited Speaker: Sven Amrhein – Roche, Basel

Automated formulation development of novel complex protein formats

Short Lectures:

Dillen Augustijn / Asmund Rinnan - University of Copenhagen
Applying Multivariate Data Analysis to Protein Fluorescence in Formulation Screening

Lorenzo Gentiluomo / Dierk Roessner - Wyatt Technology Europe
Boosting therapeutic protein development by publicly available datasets including comprehensive biophysical and computational characterization

17.40 End of day one
19.45 Conference Dinner in the old town of Heidelberg

Order of sessions can be changed.